WebT2 - A different class of mammalian DNA topoisomerase I inhibitors. AU - Chen, A. Y. AU - Yu, C. AU - Gatto, B. AU - Liu, L. F. PY - 1993. Y1 - 1993. N2 - A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor and antimicrobial activities. We show that DNA topoisomerase (Topo) I may be a pharmacological target of MGBLs. WebJul 26, 2024 · Topoisomerase II alpha is a potential target for the treatment of human diseases such as breast cancer. In this article, we attempted to discover a novel anticancer drug. We have used the topoisomerase II alpha protein-Homo sapiens (Human) to hierarchically screen the Maybridge database.
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WebTopoisomerase inhibitors (such as etoposide) are drugs that interfere with the action of topoisomerase enzymes (topoisomerase I and II). Topoisomerase enzymes control … WebTopoisomerase compound (inhibitors, antagonists, modulators) with high quality and purity, chemical tool in various assays for drug discovery and biological research, potent, … ceiling hatches for plasterboard
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WebTopoisomerase II Inhibitors Accession Number DBCAT000549 Description. Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a … WebAug 14, 2006 · drugs, for example farnesyl-transferase inhibitors. 19 A limiting factor in the use of topoisomerase-II targeting drugs is the significant tox-icity that develops with the cumulative use of these drugs. Thus, there is an urgent need for the development of future treatment reg-imens that may reduce the total dose of these drugs by combining WebTopoisomerase inhibitors are used to treat various types of cancer, such as colon cancer, leukemia, ovarian, and small-cell lung cancer. Common side effects of topoisomerase inhibitors include fatigue, gastrointestinal problems like diarrhea, hair loss, anemia, and increased risk of infection. Some patients may also experience more severe side ... buy $25 visa gift card