WebMar 21, 2024 · GeneCards Summary for SEMA7A Gene. SEMA7A (Semaphorin 7A (John Milton Hagen Blood Group)) is a Protein Coding gene. Diseases associated with SEMA7A … WebMar 7, 2024 · Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemostasis, and arterial thrombosis. …
Red blood cell-derived semaphorin 7A promotes …
WebSep 1, 2008 · Sema3B found in the conditioned medium of such cells is almost completely cleaved by furin-like pro-protein convertases, generating inactive 61- and 22-kDa … WebOct 13, 2024 · Semaphorin 7A (Sema7A) and its receptor β1 integrin have been reported to participate in the development of atherosclerosis. However, the role of Sema7A and β1 integrin in endothelial cell injury and endothelial‑to‑mesenchymal transition (EMT) in atherosclerosis remains undetermined, to the best of our knowledge. fall cushion ideas
Red blood cell-derived semaphorin 7A promotes thrombo …
The above experiments have shown that Sema7a enhances platelet activation and PNC formation in the setting of myocardial IR. To test whether Sema7a directly acts on platelets, we first assessed its effects on platelet function in standard aggregometry. Unexpectedly, Sema7a did not induce any … See more The number of PNCs increases in myocardial tissue during MIRI9. The detrimental effects of PNCs have been demonstrated in other organs, such as the lung, where … See more The profound increase in Sema7a in plasma of patients and mice with myocardial ischemia raised the possibility that it has a functional role in the progression of … See more To further investigate the role of Sema7a in myocardial IR injury, we employed Sema7a−/− animals and their littermate controls. Since Sema7a is involved in … See more Next, we sought to identify the cellular source of soluble Sema7a that mediated the observed pathogenic effect. Sema7a is expressed in several organs and tissues, … See more WebSep 29, 2024 · B The homozygous p.R148W mutation in SEMA7A was further confirmed by Sanger sequencing. C The protein domain architecture of SEMA7A and conservation of the R148 position in Vertebrata. D Structures of WT SEMA7A and R148W mutant show local conformational changes, as a result of the replacement of an arginine (carbon atoms in … WebMar 21, 2024 · SEMA7A (Semaphorin 7A (John Milton Hagen Blood Group)) is a Protein Coding gene. Diseases associated with SEMA7A include Cholestasis, Progressive Familial Intrahepatic, 11 and Blood Group, John … contrasting localities