WebThe enzyme lysine cyclodeaminase, which catalyzes the oxidative cyclization of l -lysine to l -pipecolic acid, has been identified in the rapamycin gene cluster. Cloning of the … Web"Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase". Journal of Bacteriology. 180 (4): 809–14. PMC 106958. PMID 9473033. ^ Gatto GJ, Boyne MT, Kelleher NL, Walsh CT (March 2006). "Biosynthesis of pipecolic acid by RapL, a lysine ...
Enhancement of l-Pipecolic Acid Production by Dynamic Control …
Web1 ian. 2024 · Lysine cyclodeaminase (LCD) catalyzes the piperidine ring formation in macrolide-pipecolate natural products metabolic pathways from a lysine substrate … WebL-lysine cyclodeaminase Reaction catalysed; L-lysine => L-pipecolate + NH4(+) Comment(s) The enzyme produces the non-proteinogenic amino acid L-pipecolate, which is … define sheltered housing
Optimized conversion of L-lysine to L-pipecolic acid
Web1 mai 2007 · Lysine cyclodeaminase (LCD) catalyzes the piperidine ring formation in macrolide-pipecolate natural products metabolic pathways from a lysine substrate … WebSequencing of a 40-kb DNA segment of the FK506 gene cluster from Streptomyces sp. MA6548 has revealed two additional polyketide synthases (PKS) genes fkbB and fkbC which lie upstream of fkbA , a PKS gene recently shown to be responsible for the last four condensation steps of the FK506 biosynthesis [Motamedi, H., Cai, S. J., Shafiee, A. & … Web23 sept. 2024 · Compounds 10 and 11 are the products of incubating lysine with SwHalB and lysine cyclodeaminase; compound 12 is the product of incubating ornithine with … define sheltered workshop