Iron metabolism in cancer
WebAug 5, 2024 · Iron chelators have long been a target of interest as anticancer agents. Iron is an important cellular resource involved in cell replication, metabolism and growth. Iron metabolism is modulated in cancer cells reflecting their increased replicative demands. Originally, iron chelators were first developed for use in iron overload disorders, however, … WebJan 11, 2024 · Since iron adds to shaping major hallmarks of cancer, we emphasize innovative therapeutic strategies to address the iron pool of tumor cells or cells of the tumor microenvironment for the treatment of cancer. Keywords: iron chelators; iron homeostasis; lipocalin-2; macrophage polarization; tumor progression. Publication types Review MeSH …
Iron metabolism in cancer
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WebDec 28, 2024 · Iron is an essential element for cell proliferation and homeostasis by engaging in cell metabolism including DNA synthesis, cell cycle, and redox cycling; however, iron overload could contribute to tumor initiation, proliferation, metastasis, and … WebIron is an essential metal for cellular metabolism. The reduced form of iron is a cofactor in numerous redox reactions in the cell and is therefore required for many vital physiological …
WebApr 18, 2013 · Many types of cancer cells reprogramme iron metabolism in ways that result in net iron influx. They upregulate proteins that are involved in iron uptake, such as … WebDec 28, 2024 · However, it is still debatable whether iron dysregulation is the cause or the consequence of tumor development, although iron metabolism is well recognized to be …
WebDec 27, 2024 · This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in … Web2 days ago · Liver cancer is the third leading cause of cancer death and the sixth most common cancer type worldwide. ... Endocrinology & Metabolism; Gastroenterology; ... Liver cancer research: Iron-dependent ...
WebTransferrin (Tf) is an endogenous protein that transports iron into cells through the cell membrane's TfR. There is a growing body of evidence that TfR expression in HCC is much higher than that in healthy tissues because liver cancer cells show upregulated iron metabolism. Therefore, Tf has been utilized as a specific tumor-guiding unit to ...
WebApr 9, 2024 · Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism must be tightly controlled within cells. Whilst fundamental to many cellular … short sleeve polo shirts with pocketsWebFeb 2, 2024 · Cancer is a leading cause of human mortality worldwide ... As we reported, derangement of iron metabolism is the key pathogenic mechanism for asbestos‐induced carcinogenesis both on mesothelial cells 6 , 8 and macrophages. 36 , 37 , 38 Iron addiction with ferroptosis resistance may represent the pathogenesis. 39 , ... sanyo ac serviceWebp53 is among the most critical tumor suppressor genes and is the most extensively studied gene in tumor biology within the past 40 years [1]. Due to its multiple functions in tumor, p53 has been recognized as a promising target to treat cancer [2]. In order to leverage the crucial roles of p53 in tumor therapy, it is necessary to illuminate the exact mechanisms for p53 … sanyo ac service center near meWebOct 25, 2024 · In response to inflammatory situations such as infection, cancer, and various chronic inflammatory states, the plasma iron concentration decreases, and macrophages and other cell types sequester iron. ... Defining the integration of iron metabolism under normal physiologic conditions is an essential forerunner to understanding how these ... short sleeve polo shirt womenWebBackground: Iron metabolism related genes participate in cell proliferation, cell growth, and redox cycling in multiple cancers. Limited studies have revealed the roles and clinical … short sleeve polyester topsWebDec 27, 2024 · This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in … sanyo air conditioner blowerWebApr 9, 2024 · Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism must be tightly controlled within cells. Whilst fundamental to many cellular … short sleeve polo sweater