WebFeb 28, 2024 · Objective: To evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization after high-dose immunosuppressive therapy (HDIT) and …
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WebImportance: Most patients with relapsing-remitting (RR) multiple sclerosis (MS) who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability. High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT) may, in contrast, induce sustained remissions in … WebOct 1, 2003 · HDIT included fractionated total body irradiation (TBI) delivered as 200 cGy fractions, 2 fractions per day, on day -5 and day -4, for a total dose of 800 cGy; cyclophosphamide (Cy; 60 mg/kg intravenously) on each of days -3 and -2; and equine antithymocyte globulin (ATG [15 mg/kg per day intravenously]; ATGAM; Pharmacia, … royal pines gold coast resort
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